| 摘要 |
NEW MATERIAL:3-Hydroxy-4-(hydroxymethyl)benzoic acid expressed by formula I and a salt thereof. USE:A medicine, which is a substance, having immunological activating action without cytotoxicity, and useful for immunological deficiency disease of an organisms with cancer, immunization and chemotherapy of cancer and prevention of metastasis. PREPARATION:An ester expressed by formula II (R<1> is alkyl; R<2> is H or lower alkyl) is reduced in the presence of a reducing agent, e.g. NaBH4, in a solvent, e.g. absolute methanol, at room temperature- while heating, etc. and the residual ester groups are hydrolyzed in the presence of an alkali (earth) metal hydroxide, e.g. NaOH, in an organic solvent, e.g. methanol, at room temperature- while heating to afford the aimed compound expressed by formula I.
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