Process for preparing optically active indoline-2-carboxylic acid.

摘要

A process for preparing optically active indoline-2-carboxylic acid by an optical resolution, which comprises subjecting a racemic ester of (R,S)- indoline-2-carboxylic acid having the general formula [(R,S)-I] to the action of an enzyme or a microorganism having a stereo-selective esterase activity, which is capable of asymmetricaly hydrolyzing the racemic ester [(R,S)-I] to give optically active indoline-2-carboxylic acid having the formula [11<Sup>*</Sup>] so as to produce the hydrolysis product, i.e. optically active indoline-2-carboxylic acid [11<Sup>*</Sup>] and an unreacted optically active ester of indoline-2-carboxylic acid having the general formula [i<Sup>*</Sup>], isolating each optically active form, and further, if necessary, hydrolyzing the obtained optically active ester [I*] to give an optical antipode of the acid [II*].

According to the process of the present invention, optically active indoline-2-carboxylic acid with a high optical purity can be prepared in a simple process with a good yield.