| 摘要 |
NEW MATERIAL:The macrocyclic polyamine of formula (n is 1-5) and a derivative of said polyamine wherein all or a part of the carboxyl groups are reduced to -CH2OH. USE:A ureterolithotriptic agent. It has excellent activity within the physiological pH range. It is infused as it is to the urinary tract or to the kidney with a pump to dissolve and remove the existing stones. PREPARATION:The compound of formula can be prepared, e.g. by reacting 1,4,7,10,13,16-hexaazacyclooctadecane with a halogenated organic acid such as chloroacetic acid, chlorobutyric acid, etc. in an aqueous solution of an alkali.
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