| 摘要 |
<p>The present invention relates to novel isomers of PGAs, PGDs, PGEs, PGFs, 6-keto-PGE<Sub>1</Sub>s, 6-keto-PGF<Sub>1</Sub>s, PGl<Sub>2</Sub>s, 6,9a-nitrilo-PGl<Sub>1</Sub>s and 6,α-methano-PGl<Sub>2</Sub>s, having a specific steric configuration, which are replaced by an alkyl (C<Sub>1</Sub> to C<Sub>8</Sub>)-substituted cycloalkyl (C<Sub>4 </Sub>to C<Sub>7</Sub>) group in (1S, S) form, in (1S, R) form or in cis form at the 15-, 16- or 17-position of the PG skeleton, and, alkyl esters thereof, non-toxic salts thereof, non-toxic acid addition salts thereof and cyclodextrin clathrates thereof, possessing more potent PG-like pharmacological activity than other isomers.</p> |
