| 摘要 |
<p>NEW MATERIAL:A compound expressed by formula I (R<1> is aryl, arlower alkyl or lower alkyl which may be substituted by a substituent group selected from the group of halogen, cyclolower alkyl, halolower alkyl and aryloxy; R<2> is H or aryl; R<3> and R<4> are H or lower alkyl; X is O or S; R<2> is aryl when R<1> is methyl) and salt thereof. EXAMPLE:Bis(tert-butylamine) salt or [3-(phenyl)ureidomethylene]bis(phosphonic acid). USE:With bone resorption inhibitory activity and useful for treating osteopathy. PREPARATION:A compound expressed by formula II (R<5>-R<8> are protected OH) is hydrolyzed in the presence of, e.g. a base, Lewis acid, etc., to subject the OH-protecting groups to elimination reaction.</p> |
