Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes

摘要

A high flux transdermal nitroglycerin therapeutic system is disclosed which is capable of delivering nitroglycerin through intact human skin at rates of 40 mu g/cm2hr and preferably in the range of 50-150 mu g/cm2hr. Ethanol delivered at a rate of from 250-500 mu g/cm2hr is employed as a permeation enhancer for the nitroglycerin and a rate controlling membrane formed from ethylene vinyl acetate having a vinyl acetate content greater than 11% and preferably between 12-18% provides the appropriate rate control for both the drug and the permeation enhancer. This system is suitable for use in treatment of angina pectoris and congestive heart failure.