发明名称 Process for the preparation of a composition which is suitable for the prophylaxis and therapy of adverse changes in the hygiene on epithelial cells and can be used as specific and accelerated in vivo nutrient medium
摘要 The essence of the invention is, for specific multiplication of the Lactobacillus acidophilus living on epithelial tissues, where appropriate Lactobacillus bifidus, Propionibacterium and/or Corynebacterium etc, that an in vivo utilisable carbon source of 0-50% by weight, preferably one or more carbohydrates, lactic acid and/or glycerol, a nitrogen source of 0-20% by weight, preferably proteins, protein breakdown products or urea, and additional materials of 0-20% by weight, preferably salts, vitamins, growth factors, antiviral or antiphage agents and/or immunity-increasing or immunity-inhibiting agents are mixed and diluted 0-20-fold with the carrier materials customary in pharmaceutical formulation, these being added to the amount of the carbon or nitrogen source; the acidity of the mixture is adjusted by an acid, preferably by lactic acid, to a pH of 3.0-6.5; where appropriate the mixture is heat-treated between 30 and 120 DEG C and then converted by a process known per se into a therapeutic composition, preferably suppositories, tablets, ointment, chewing gum, coated tablets, injection or spray.
申请公布号 DE3510531(A1) 申请公布日期 1986.10.02
申请号 DE19853510531 申请日期 1985.03.22
申请人 LICENCIA TALALMANYOKAT ERTEKESITOE VALLALAT 发明人 MEHESZ,ERNOE,DR.;MEHESZ,ERNOE
分类号 A61K45/06;A61K31/19;A61K31/70;A61K35/66;A61K35/74;A61K38/00;A61K38/16;A61P1/12;A61P31/00;(IPC1-7):C12N1/00;C12N1/04;C12N1/20;A61K37/02;A61K39/12;A61K31/375;A61K9/06;A61K9/68;A61K9/20 主分类号 A61K45/06
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