| 摘要 |
PURPOSE:To produce the titled compound useful as an intermediate for various pharmaceuticals in high yield, by reducing thiophene-2-acetamide with a hydride reagent. CONSTITUTION:The objective compound of formula II is produced by reducing the compound of formula I with a hydride reagent (e.g. LiAlH4). The amount of the hydride reagent is about >=2mol, preferably about 2.5-5mol per 1mol of the compound of formula I. The reaction is carried out in a solvent (e.g. diethyl ether) at a temperature between 0 deg.C and the boiling point of the solvent. The objective compound can be produced from an easily available raw material in the high yield with simple process.
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