Substituted 1,8-naphthyridinones, processes for their preparation and pharmaceutical compositions containing them.

摘要

Substituted 1,8-naphthyridinones of formulae V, VI or VII <CHEM> wherein n is 1 or 2; R<1> and R<2> may be combined to form a bond, or R<1> is hydrogen and R<2> is OR, halogen or NR<3>R<4>; R is hydrogen, carboxylic acyl or carbamyl; R<3> and R<4> are independently hydrogen or alkyl having from 1 to 6 carbon atoms, or R<3> and R<4> may be combined with the nitrogen to which they are attached to form a pyrrolidino, piperidino, morpholino or piperazino ring; R<5> is hydrogen or carboxylic acyl; and Y is CH or N. The compounds possess anti-allergic, anti-inflammatory, cytoprotective activity and an immuno-suppressing effect.