发明名称 |
CEPHALOSPORIN COMPOUNDS AND SLATS THEREOF,AND THEIR PRODUCTION |
摘要 |
NEW MATERIAL:A compound expressed by formula I {R<1> represents (substituted) lower alkyl; R<2> represents hydroxy lower alkyl, cyano, lower alkylthio, 5-methyl-2-oxo-1,3-dioxolen-4-yl, carbonyl expressed by -CORA [RA represents (substituted) lower alkyl], etc.; R<3> represents H or lower alkyl; n is 1-3} or salt thereof. EXAMPLE:(Z)-7-[alpha-( 2-Amino-4-thiazolyl )-alpha-(methoxyimino)acetamide]-3-(1-cyano methyl-4-pyridinio)thiomethyl-DELTA<3>-cephem-4-carboxylate expressed by formula II. USE:An antibacterial agent against Gram-positive bacteria and Gram-negative bacteria. PREPARATION:A 3-pyridinylthiomethyl-DELTA<3>-cephem-4-carboxylic acid derivative expressed by formula III (R<4> represents H or amino-protecting group; R<5> represents H or COOH-protecting group) is reacted with a (substituted) lower alkyl halide or sulfonate expressed by formula IV (R<20> represents hydroxy lower alkyl, etc.; X represents halogen atom, etc.). |
申请公布号 |
ZA8600405(B) |
申请公布日期 |
1986.09.24 |
申请号 |
ZA19860000405 |
申请日期 |
1986.01.20 |
申请人 |
YAMANOUCHI PHARMACEUTICAL CO.,LTD. |
发明人 |
TADAO SHIBANUMA;ATSUKI YAMAZAKI;AKOI KODA;TETSUYA MAEDA;KOHJI NAKANO;NORIAKI NAGANO;YUKIYASU MURAKAMI;RYUICHIRO HARA;TAKUMI TAKAHASHI |
分类号 |
C07D501/36;A61K31/545;A61K31/546;A61P31/04;C07D;C07D499/00;C07D501/00;C07D513/00 |
主分类号 |
C07D501/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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