1,4-Dihydropyridines.

摘要

Compounds having calcium channel antagonist activity of the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="31" wi="57" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R, and R<Sub>2</Sub> are each independently amino, trifluoromethyl, pentafluoroethyl, alkoxy, lower alkenyl, or lower alkynyl or branched or unbranched lower alkyl, which is unsubstituted or is substituted with cyano, hydroxy, acyloxy, hydrazino, lower alkyl amino, or di-(lower alkyl)-amino or 5 or 6 membered saturated nitrogen-containing heterocyclic-1-yl. which is unsubstituted or is substituted with oxo, hydroxy, alkyl, and hydroxy (lower alkyl) R<Sub>3</Sub> is straight- or branched-chain C, to C<Sub>12</Sub> alkyl, alkenyl, alkynyl, or cycloalkyl, and is either unsubstituted or substituted with hydroxy, acyloxy, cyano, di(lower alkyl) amino 5- or 6- membered saturated nitrogen-containing heterocyclic -1-yl or R<Sub>3 </Sub>is -A-R<Sub>4</Sub>, A is a straight- or branched-chain hydrocarbon moiety containing from 2 to 12 carbon atoms and from 0 to 2 double bonds, R<Sub>4</Sub>, is selected from the group consisting of:
<Chemistry id="chema02" num="0002"><Image id="ia02" he="71" wi="84" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>R<Sub>5</Sub> is hydrogen, nitro, cyano, azido, amino, trifluoromethyl, alkylamino, dialkylamino, halo, carboxyl, carbalkoxy, alkyl, alkenyl, alkynyl, cycloalkyl, acylamino, carboxamido, sulfonamido, and SO<Sub>m</Sub>-(lower)alkyl where m Is 0,1, or 2 and R<Sub>6</Sub> is aryl or heteroaryl or a pharmaceutically-acceptable salt thereof are disclosed. Also disclosed is a method of treating hypertension and other disorders by administering an effective amount of a compound of the present invention.