发明名称 NOVEL NB-QUATERNARY DIBROM DERIVATIVES OF AJMALINE, ISOAJMALINE, SANDWICINE AND ISOSANDWICINE, MANUFACTURE AND ANTIARRYTHMIC
摘要 1. Nb -quaternary compounds of the general Formula I, see diagramm : EP0182271,P17,F1 wherein R stands for an alkyl group with 1 - 6 carbon atoms, which may optionally be substituted by hydroxy or halogen on a carbon atom which is not bonded to nitrogen, for an alkenyl group with 3 to 6 carbon atoms, the double bond of which is not directly bonded to the nitrogen atom, for a phenylalkyl group with 2 to 3 carbon atoms in the alkylene chain, which may optionally be substituted in the phenyl ring by alkoxy with 1 - 3 carbon atoms or halogen, or stands for a group a, see diagramm : EP0182271,P17,F2 wherein Z is an alkylene chain with 2 - 3 carbon atoms or the 2-hydroxypropylene chain, R1 and R2 are each alkyl with 1 - 3 carbon atoms, or R1 and R2 , together with the nitrogen atom to which they are bonded, represent a heterocycle from the group pyrrolidine, piperidine, azepine and morpholine, or if Z is an alkylene chain, R1 is alkyl with 1 - 3 carbon atoms and R2 , together with the nitrogen atom to which it is bonded and the C atom of the alkylene chain Z which adjoins said nitrogen atom, represents a heterocycle from the group pyrrolidine and piperidine, and A**- is the anion of a physiologically compatible inorganic or organic acid.
申请公布号 JPS61204187(A) 申请公布日期 1986.09.10
申请号 JP19850261632 申请日期 1985.11.22
申请人 KALI CHEM PHARMA GMBH 发明人 BUORUFUGANGU KEERUBATSUHA;UBUE SHIEEN
分类号 A61K31/435;A61P7/02;A61P9/00;C07D471/22 主分类号 A61K31/435
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