发明名称 |
DERIVAT AV KANAMYCIN A ELLER B. |
摘要 |
<p>1-N-[ omega -amino- alpha -hydroxyalkanoyl] kanamycins A and B of the formula I <IMAGE> in which R represents OH or NH2, are prepared by acylation of polysilylated kanamycin A or B, or polysilylated kanamycin A or B which has a protective group other than silyl on the 6'-amino group, with an acylating derivative of an acid of the formula II <IMAGE> in which n is an integer from 0 to 2 and B is an amino protective group, in an essentially anhydrous organic solvent and by subsequent removal of all blocking groups. The compounds have therapeutic properties.</p> |
申请公布号 |
NO154697(B) |
申请公布日期 |
1986.08.25 |
申请号 |
NO19830001197 |
申请日期 |
1983.04.05 |
申请人 |
BRISTOL-MYERS COMPANY |
发明人 |
CRON, MARTIN JOHN;KEIL, JOHN GERARD;LIN, JENG SHYONG;RUGGERI, MARIANO VECCHIO;WALKER, DEREK |
分类号 |
C07H15/234;C07H15/236;C07H23/00;(IPC1-7):C07H23/00 |
主分类号 |
C07H15/234 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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