The present invention is concerned with the simultaneous formation and encapsulation of small particles of organic compounds whose solubility in water is greater at a first pH than at a second pH by concurrently precipitating said organic compounds as small particles and forming a coacervate of an anionic (or cationic) surfactant and an amphoteric surfactant. The process is preferably used to prepare a readily soluble encapsulated pharmaceutically active compound.
申请公布号
US4606939(A)
申请公布日期
1986.08.19
申请号
US19840621133
申请日期
1984.06.15
申请人
THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
发明人
FRANK, SYLVAN G.;BRODIN, ARNE F.;CHEN, CHIH-MING J.;SHRIVASTAVA, RATNESH