| 摘要 |
<p>Method for producing L-phenylalanine by hydrogenation of acetamidocinnamic acid in the presence of a complex of a metal M of the group VIII of the periodic classification and by hydrolysis of the resultant product of the hydrogenation reaction. The hydrogenation reaction is carried out in the presence of a solvent under pressure conditions higher or equal to atmospheric pressure conditions, at a temperature comprised between -50oC and +10oC, during a time interval shorter than or equal to 300 minutes, the molar ratio between acetamidocinnamic acid and said metal being higherthan or equal to 100, the complex of metal M being selected amongst on one hand those of the formula MZ¿q-r?Lr and on the other hand those of the formula (MZq-rLr)?+A-¿, wherein r is equal to 1 or 2, q is the co-ordination degree of the metal M, Z is an atom or a molecule capable of complexing the metal M, A- is a hardly co-ordinating and sterically hindered anions and L is a chiral phosphorated ligand selected among those of the formula (I) wherein W is a dihydrocarbylphosphinoxy radical having the formula W = OP(R)¿2? wherein R is a hydrocarbonic radical selected amongst alkyl, aryl and cycloalkyl radicals, R1 is selected amongst the hydrogen atom and hydrocarbonic radicals, R3 and R4, necessarily different from each other, are selected amongst the hydrogen atom and hydrocarbonic radicals optionally carrying at least a function selected amongst the alcohol, thiol, thioether, amine, imine, acid, ester, amide et ether functions, and R5 and R6 are selected amongst the hydrogen atom and the optionally functionalized hydrocarbonic radicals. Application to the obtention of L-phenylalanine in a chemically and optically pure form.</p> |
