BIOCOMPATIBLE CONTAINER ENCLOSING FUNCTIONAL BLOOD PLATELETS LACKING IMMUNOGENICITY AND METHOD OF PRODUCING SAME

摘要

The effect of ultraviolet (UV) radiation on platelet concentrates collected in a plastics container (2), particularly in a polypropylene bag. Samples irradiated at 310 nm for 30 minutes at a dose of 774 J/M<2> show no loss of platelet function as determined by ADP, collagen, or ristocetin-induced aggregation. Lymphocytes isolated from irradiated units are unable to act as responders or stimulators in a mixed lymphocyte reaction. The invention provides a device and a method of UV irradiation of platelet concentrates resulting in transfusible cell suspension unable to evoke immunological response while retaining normal platelet function.