| 摘要 |
PURPOSE:To obtain an amide compound useful as drugs, agricultural chemicals, their raw materials and intermediates by one stage in high yield, by reacting a Schiff base compound with a silane compound and a carboxylic acid derivative under a mild condition. CONSTITUTION:A schiff base compound shown by the formula I (R<1> and R<2> are alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, etc.) is reacted with a compound shown by the formula II (X, Y, and Z are H, or halogen) and a carboxylic acid derivative shown by the formula III (R<3> is as shown for R<1>; M is halogen, or OCOR<3>) in a molar ratio of 1:1-2:1-1.2 in a solvent such as benzene, chloroform, etc., at -20-150 deg.C for 5min-10 days, to give a com pound shown by the formula IV. EFFECT:A reaction product is easily purified. |
