发明名称 |
SURFACTANT AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
摘要 |
<p>SURFACTANT AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME A surfactant having the capacity of reducing the surface tension in pulmonary alveoli significantly is provided. The surfactant consists essentially of, based on the total weight of the surfactant, 50.6-85.0% of a choline phosphoglyceride, 4.5-37.6% of an acid phospholipid, 4.6-24.6% of a fatty acid or its analogue and 0.1-10.0% of a lipoprotein derived from the lung of a mammal. These components cooperate to form a kind of film at a gas-liquid interface, within pulmonary alveoli and reduce the surface tension. A pharmaceutical composition comprising the surfactant is useable for the clinical treatment of respiratory distress syndrome.</p> |
申请公布号 |
CA1208129(A) |
申请公布日期 |
1986.07.22 |
申请号 |
CA19840449223 |
申请日期 |
1984.03.09 |
申请人 |
TOKYO TANABE COMPANY, LIMITED |
发明人 |
TSUNETOMO, TAKEI;YOSAKU, KANAZAWA;KAZUO, MASUDA;YUJI, TANAKA |
分类号 |
A61K31/685;A61K9/00;A61K31/16;A61K35/42;A61K38/00;A61K38/17;A61P11/00;B01F17/00;B01F17/14;B01F17/30;C07F9/02;(IPC1-7):A61K35/42;A61K31/66 |
主分类号 |
A61K31/685 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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