LEUKOTRIENE ANTAGONISTS, THEIR PRODUCTION, AND COMPOSITIONS CONTAINING THEM

摘要

Compounds of the formulae: and their pharmaceutically acceptable (including acid-addition) salts, which are novel, are antagonists of leukotrienes of C4, D4 and E4, the slow reacting substance of anaphylaxis. They can be made into pharmaceutical compositions by incorporating them in a pharmaceutical carrier. In the formulae, each R is H, OH, SH, C1-6 alkyl, C2-6 alkenyl, CF3, C1-6 alkoxy, C1-6 alkythio, phenyl, phenyl having C1-3 alkyl or halogen substitution, phen (C2-4 alkyl), halogen, amino, N(R4)2, COOR4 or CH2OR4 where R4 is H or C1-6 alkyl, formyl, CN, CF3S or NO2; each R<1> is R4; OR4; COOR4; N(R4)2; SR4; CH2OR4 or CHO; or together R min and R min are O, CH2 or Y is oxyge, sulfur, sulfoxide, sulfone, @ = NR11, = NR12, = N - CO - R13 or - N - CN, where R11 is C1-4 alkyl, R12 is H or C1-4 alkyl and R13 is C1-4 alkyl or C1-4 alkoxy; Y min is Y, -CH2- or - @ -; each R1 is hydrogen or C1-3 alkyl; each m is an integer from 0 to 6; where Z is O, S, CH2, H and OH, C1-4 alkenyl, or = N - R14, where R14 is OH, CN, COOH, halogen, formyl, C1-6 acyl, C1-6 alkyl, C1-6 alkoxy, C1-6 halogenated alkyl, phenyl, or phenyl having C1-3 alkyl or C1-3 alkoxy substitution; each R6 is H or C1-4 alkyl; each R7 is H, OH or C1-4 alkyl; each R8 is H or C1-4 alkyl and is absent when the two indicated carbons are triply bonded; R5 is COOR4; CH2OH; CHO; tetrazole; NHSO2R14; CONHSO2R14 hydroxymethylketone; CN; CON(R7)2; a monocyclic or bicyclic heterocyclic ring containing an acidic hydroxyl group; or COOR15 where R15 is: where each s is independently 0-3, R6 is as defined above and R16 is (A) a monocyclic or bicyclic heterocyclic radical containing from 3 to 12 nuclear carbon atoms and 1 or 2 N heteroatoms or one N and one S heteroatom, each ring in the heterocyclic radical being formed of 5 or 6 atoms, or (B) W-R17 where W is O, S or NH and R17 contains up to 21 carbon atoms and is (1) a hydrocarbon radical or (2) an acyl radical or an organic acylic or monocyclic carboxylic acid containing not more than 1 heteroatom in the ring; each of r and q is 0-20 but r + q does not exceed 20; and p is 0 or 1; R3 is C1-6 alkyl or C3-6 alkenyl; R9 is C1-6 alkyl, C1-6 alkoxy or (CH2)rR5, where r and R5 are as defined above; and R10 is H, C1-6 alkyl; R4CO- or R4OCH2, where R4 is as defined above. The compounds are prepared by condensing together two compounds having appropriately substituted benzene rimgs, one of which contains a halogen atom in the chain containing Y and Y min , which removes a hydrogen atom from the ring of the other compound.