| 摘要 |
PURPOSE:To obtain inexpensively the titled compound useful for peptide synthe sis, by reacting lysine hydrochloride with an organic acid anhydride, acetic formic anhydride in the presence of an alkali metal salt of an organic acid and formic acid at a specific temperature. CONSTITUTION:Lysine hydrochloride is reacted with an organic acid anhydride selected from acetic anhydride and acetic formic anhydride in the presence of both an alkali metal salt of an organic acid and formic acid at 0-20 deg.C to give N<2>-formyllysine. The lysine hydrochloride used in this method may be either lysine monohydrochloride or lysine dihydrochloride. In this method, an amount of formic acid and acetic anhydride are small, and the aimed substance is obtained more inexpensively when acetic formic anhydride is used. |
