Thiol based collagenase inhibitors.

摘要

The invention relates to compounds of the formula
<CHEM>
wherein R1 represents lower alkyl, phenyl or phenyl lower alkyl;
R2 and R4 represent lower alkyl; and
R3 represent lower alkyl, benzyloxyalkyl, alkoxybenzyl or benzyloxybenzyl wherein the oxyalkyl or alkoxy moiety contain 1 to 6 carbon atoms; and a, b, and c represent chiral centers with optional R or S stereochemistry, intermediates for the synthesis of said compounds and pharmaceutical compositions, especially for the treatment of rheumatoid arthritis or other collagen based degradative diseases, containing said compounds.