| 摘要 |
NEW MATERIAL:The imidazole derivative of formula I (R<1> and R<2> are H or CH3; R<3> is H or OCH3; m is number of double bonds having transconfiguration, and is 1 or 2; m is number of CH2 groups and is 2, 3 or 4; when R<2> is CH3, R<1> is also CH3, and when R<3> is OCH3, R<1> is CH3). EXAMPLE:1-[ 3-( 3-Methoxy-4-hydroxyphenyl )propenoyl ]-4-(beta-imidazol-1-ylethyl) piperazine. USE:A platelet coagulation-suppressing agent useful as a preventive for thrombosis and metastasis of cancer, etc. PREPARATION:The compound of formula I can be prepared by condensing the compound of formula II (R<4> and R<5> are CH3 or CH2OCH2CH2OCH3; R<6> is H or OCH3; when R<5> is CH3, R<4> is also CH3 and when R<6> is OCH3, R<4> is CH3) or its reactive derivative with imidazole in toluene or xylene under heating.
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