| 摘要 |
NEW MATERIAL:A compound of formula I (R<1>, R<2> are H, alkyl, substituted alkyl or aralkyl; R<1> and R<2> incorporate to form polymethylene or heteroatom- containing polymethylene). EXAMPLE:N-2,5,12-Trihydroxy-6,11-dioxo-1,2,3,4-tetrahydronapht-hacene- 2-carbon yl)morpholin. USE:Antitumor agent: It has a very simple structure with anthraquinone skeleton, free from aminosaccharides. PREPARATION:The reaction of an acylimidazole of formula II with an amine of formula III is carried out in a solvent such as tetrahydrofuran at 0 deg.C to room temperature to give the compound of formula I. |
