发明名称 |
PENEMDERIVATER. |
摘要 |
<p>New derivatives of penem and pharmaceutically acceptable salt thereof are herein disclosed; these compounds being useful as an antibacterial agent which has an extremely wide antibacterial spectrum, exhibits a high sensitivity to bacteria resistant to conventional penicillins and cephalosporing antibiotics and is excellent in its physico-chemical stability, solubility to water and biological stability, in particular, stability to decomposition by enzyme such as dehydropeptidase I in kidney, beta -lactamase; these derivatives of penem being able to be prepared by reacting 2-substituted sulfinyl derivative of penem with a thiol compound and then optionally removing protective group(s) and further alkylating the reaction product or vice versa.</p> |
申请公布号 |
NO862411(D0) |
申请公布日期 |
1986.06.17 |
申请号 |
NO19860002411 |
申请日期 |
1986.06.17 |
申请人 |
DAIICHI SEIYAKU CO. LTD. |
发明人 |
SATO, MAKOTO;TAKEMURA, MAKOTO;HIGASHI, KUNIO;SOGA, TSUNEHIKO;MATSUMOTO, HIROO;NISHI, TOSHIYUKI |
分类号 |
A61K31/43;A61P31/04;C07D471/04;C07D487/04;C07D498/04;C07D499/88;C07D513/04;C07D519/00;C07D519/06;(IPC1-7):C07D499/00 |
主分类号 |
A61K31/43 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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