摘要 |
PURPOSE:To produce the titled compound useful as an amino acid transfusion, etc., easily on an industrial scale, by reacting (+ or -)-N-carbamoyl-phenylalanine with an optically active compound, and separating the objective compound taking advantage of the solubility difference of the optical isomers to a solvent. CONSTITUTION:(+ or -)-N-carbamoyl-phenylalanine (e.g. the compound of formula) is made to react with an optically active N-hydroxyethyl-1-methylbenzylamine (abbreviated as HPA), and is optically resolved taking advantage of the solubility difference to a solvent. For example, an optically active HPA and a solvent are added to the compound of formula, dissolved by heating to obtain a supersaturated solution, and cooled to room temperature. If necessary, a small amount of the seed of a hardly soluble complex of the optically active compound of formula and HPA is inoculated to the super-saturated solution. A hardly soluble salt can be separated easily by this process.
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