| 摘要 |
NEW MATERIAL:The quinolinecarboxylic acid compound of formula I (R is H or lower alkyl; X is halogen). EXAMPLE:N-(3-chloro-4-fluorophenyl) acetamide. USE:A preparation intermediate of 8-bromo-1-cyclopropyl-6-fluoro-1,4-dihydro-7-(substitut-ed amino)-4-oxo-3- quinolinecarboxylic acid, etc. which is a novel antibacterial agent. PREPARATION:The compound of formula I wherein R is lower alkyl can be prepared by reacting the novel compound of formula II (R<1> is lower alkyl; X and Y are halogen) with an alkyl orthoformate to obtain the compound of formula III (R<2> is lower alkyl), reacting the compound with cyclopropylamine, and cyclizing the resultant compound of formula IV.
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