| 摘要 |
<p>A compound of the formula
<CHEM>
its diastereoisomers or mixtures thereof, or a pharmaceutically acid addition salt thereof;
wherein R is
<CHEM>
in which R3 and R4 are, indpeendently, lower alkanoyl, benzoyl, or benzoyl substituted by lower alkyl, lower alkoxy, halogen, or trifluoromethyl;
R2 is H, NH2, halogen, or NHR6 in which R6 is alkanoyl, benzoyl, or benzoyl substituted by lower alkyl, lower alkoxy, halogen, or trifluoromethyl;
R2 min and R3 min are, independently, lower alkanoyl, benzoyl or benzoyl substituted by lower alkyl, lower alkoxy, halogen or trifluoromethyl, or, when taken together, R2 min and R3 min are represented by a lower, C1-6, alkylidene radical; and
X is OH, acetyloxy, H,C1, SCH3, or OR5 in which R5 is H, lower alkanoyl, benzoyl, benzoyl substituted by lower alkyl, lower alkoxy, halogen, or trifluoromethyl.
<??>Also disclosed are processes for their manufacture, pharmaceutical compositions and methods for using the compounds.
<??>The compound have highly desirable central nervous system properties. </p> |
