摘要 |
<p>A dihydropyridine of the formula:- <CHEM> wherein R<1> and R<2> each is alkyl or alkoxyalkyl, wherein R<3> is alkyl, wherein benzene ring A bears one or more substituents selected from halogeno, cyano, nitro, trifluoromethyl and alkyl or bears the substituent =N-O-N= attached to the 2- and 3-positions; wherein Ar is phenyl, naphthul, tetrahydronaphthyl, indanyl or indenyl which is unsubstituted or which bears one or more substituents or Ar is a 5- or 6-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from oxygen, nitrogen and sulphur, which ring is saturated or unsaturated, and which ring is unsubstituted or bears one or more substituents, wherein p is 0 or 1; wherein q is 1, 2, 3 or 4; wherein X is -O-, -NH-, -NHCO- or -CONH-; and wherein Y is straight-or branched-chain alkylene which may optionally be interrupted by one or two groups selected from oxygen, sulphur, imino substituted imino, phenylene, substituted phenylene, pyridylene, cycloalkylene, 1,4-piperazinediyl, 1,4-piperidinediyl and amido groups; or an acid-addition salt thereof, processes for their manufacture and pharmaceutical compositions containing them. The compounds possess either beta-adrenergic blocking or calcium ion slow channel blocking properties or both such properties, and may be used in the treatment of hypertension.</p> |