| 摘要 |
Novel avermectin epoxides have the formula: …<CHEM>… in which the broken line at the 22,23-position indicates a single or a double bond; R1 is hydrogen or hydroxy and is present only when the broken line at the 22,23-position indicates a single bond; R2 is iso-propyl or sec-butyl; R3 is hydroxy or methoxy; R4 is hydroxy, alpha -L-oleandrosyloxy, or 4 min -( alpha -L-oleandrosyl)- alpha -L-oleandrosyloxy; and the dotted triangular figures at the 8,9 and 14,15 positions indicate a double bond or an epoxide, provided that at least one of the 8,9 and 14,15 positions is epoxidized. The epoxides are prepared by oxidizing an avermectin compound with a mild oxidizing agent. The avermectin epoxide compounds have utility as anti-parasitic agents and can be made into compositions suitable for that use. The compounds are also highly potent insecticides against agricultural pests. |
