PROCESS FOR THE PREPARATION OF SUBMICROSCOPIC PARTICLES, THE PARTICLES THUS OBTAINED AND THE PHARMACEUTICAL COMPOSITIONS IN WHICH THEY ARE PRESENT

摘要

The present invention provides for a process for the preparation of submicroscopic particles formed of a polymerized alkyl cyanoacrylate and containing a biologically active substance. At least one alkyl cyanoacrylate, in which the term "alkyl" denotes an alkyl radical having 1 to 12 carbon atoms, is added, with stirring, to pure water or to an aqueous solution or aqueous colloidal solution of an acid and/or of another watersoluble substance, and the stirring is continued until substantially all the alkyl cyanoacrylate has been converted to submicroscopic particles formed of polyalkyl cyanoacrylate; a biologically active substance is introduced into the reaction medium before the introduction of the monomer or after the formation of the submicroscopic particles. The submicroscopic particles are useful as carriers for substances such as medicinal substances or products for diagnosis.