| 摘要 |
<p>Naphthyridin-2(1 H)-ones, having the formula I …<CHEM>… or salts thereof, where Z is hydrogen or cyano, and Q is 2 (or 3)-furanyl, 2(or 3)-thienyl, 4(or 3)-pyridinyl or 4(or 3)-pyridinyl having one or two methyl substituents, are useful as cardiotonic agents and corresponding compounds where Z is carboxy are useful as intermediates. Also shown as intermediates are 5-(Q-CO)-6-[2(di-lower-alkylamino)-ethenyl]-2(1H)-pyridinones (II) or salts thereof, where Q is defined as above. A process for preparing the compounds (I) comprises reacting a compound (II) with formamidine, ammonia or a salt thereof.</p> |
