| 摘要 |
<p>A process for the preparation of chloro-difluorobenzene compounds of the formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="32" wi="40" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>
where R is CN or CF<Sub>3</Sub>, comprises the steps of
<UnorderedLists id="ula01" listStyle="none"><ListItem>(A) reacting an alkali metal fluoride with 4-chloro-3,5-dinitrobenzonitrile or 4-chloro-3,5-dinitrobenzotrifluoride to form the corresponding 4-fluoro-3.5-dinitrobenzonitrile or 4-fluoro-3,5-dinitrobenzotrifluoride product.</ListItem><ListItem>(B) chlorodenitrating the 4-fluoro product of step (A) to form the corresponding 3,5-dichloro-4-fluorobenzonitrile or 3,5-dichloro-4-fluorobenzotrifluoride compound.</ListItem><ListItem>(C) reacting the 3,5-dichloro-4-fluorobensonitrile or 3,5-dichloro-4-fluorobenzotrifluoride compound prepared in step (B) with an alkali metal fluoride to form the corresponding 3-chloro-4,5-difluorobenzonitrile or 3-chloro-4,5-difluorobenzotrifluoride compound.</ListItem></UnorderedLists></p> |
