| 摘要 |
NEW MATERIAL:The pyrimidine derivative of formula I [Ar is nitro, haloalkyl, alkoxy, or substituted aryl of formula II (R<4>-R<6> are H or halogen; l is 0-6); R<1> is esterified carboxy, alkanoyl, hydroxyalkyl, group of formula III (R<7> and R<8> are H or N-containing heterocyclic group, etc.), or group of formula IV (A is alkylene); R<2> is H, alkyl or group of formula V (B is A); R<3> is alkyl or aryl] and its salt. EXAMPLE:6-Methyl-5-(4-methylpiperazin-1-ylmethyl)-4-(3-nitroph-en-yl)- 2-phenyl pyrimidine. USE:Remedy for cerebrovascular disease such as cerebral apoplexy. PREPARATION:The compound of formula VIII which is one of the compound of formula I can be prepared e.g. by reacting the compound of formula VI or its salt with the compound of formula VII or its salt. |
