| 摘要 |
Compounds of the formula <IMAGE> wherein: R is phenyl, phenyl monosubstituted, disubstituted, or trisubstituted by (C1-C8) alkyl, (C1-C8)alkoxy, hydroxy, chlorine, bromine, iodine, fluorine, trifluoromethyl, nitro, (C1-C6)alkylcarbonyl, benzoyl, or phenyl; 1-, or 2-naphthyl; 1-, 2-, or 3-indenyl; 1-, 2-, or 9-fluorenyl; 1-, 2-, or 3-piperidinyl; 2- or 3-pyrrolyl; 2- or 3-thienyl; 2- or 3-furanyl; 2- or 3- indolyl; 2- or 3-thianaphthenyl; or 2- or 3-benzofuranyl; R1 is hydrogen, (C1-C8)alkyl, benzyl, or phenethyl; X and Y independently, are hydrogen, fluorine, chlorine, or bromine; and A is a divalent radical of the formula: <IMAGE> wherein R2 is hydrogen, methyl, or ethyl, and m and n, independently, are an integer from 0 to 4, provided that m+n cannot be greater than 4; -(CH2)p-D-(CH2)q-, wherein D is oxygen, or sulfur, p is an integer from 2 to 4, and q is an integer from 0 to 2, provided that p+q cannot be greater than 4; or -(CH2)rCH=CH(CH2)s-, wherein r is an integer from 1 to 3 and s is an integer from 0 to 2, provided that r+s cannot be greater than 3; or a non-toxic, pharmaceutically-acceptable acid addition salt thereof; provided that when each of X and Y in Formula I is hydrogen, R cannot be phenyl; are MAO inhibitors useful for treating depression. Processes and intermediates for preparing the compounds of Formula I or II are also described. |
