LEUKOTRIENANTAGONISTER

摘要

Compounds of formula (I) …… in which R1 is C8to C13 alkyl, C7 to C12 alkoxy, C7 to C12 thioalkyl, C10 to C12 1-alkynyl, 10-undecynyloxy, 11-dodecynyl, phenyl-C4 to C10 alkyl, phenyl-C3 to C9 alkoxy, phenylthio-C3 to C9 alkyl with the phenyl optionally mono substituted; R2 is hydrogen, bromo, chloro, methyl, trifluoromethyl, hydroxy, methoxy or nitro; or R1 is hydrogen and R2 is C8 to C13 alkyl, C7 to C12 alkoxy, C7 to C12 thioalkyl, C10 to C12 1-alkynyl, 10-undecynyloxy, 11-dodecynyl, phenyl-C4o to C10 alkyl, phenyl-C3 to C9 alkoxy, phenylthio-C3 to C9 alkyl with the phenyl optionally mono substituted;… Y is COR3, …… or (CH2)0-1-C-tetrazolyl;… R3 is hydroxy or amino; R4 is hydrogen, methyl, methoxy, fluoro or hydroxy; m is 0, 1 or 2;… R is ……, CH(CO2H)CH2CO2H, CH2CH2Z or …… n is 0, 1 or 2; R5 is hydrogen, amino or NHCOCH2CH2CH(NH2)CO2H; R6 is hydroxy, amino or NHCH2CO2H; Z is SO3H, SO2NH2 or CN; R7 is hydrogen, C1 to C4 alkyl or C3 to C4 alkenyl; R8 is hydrogen, C1 to C4 alkyl, carboxyl or carboxamido, or (CH2)pCO2H, in which p is 1 or 2, when R7 and R9 are hydrogen or C1 to C4 alkyl; and R9 is hydrogen, C1 to C4 alkyl or CH2CO2H; compositions containing then and their use in therapy as leukotriene antagonists, for example in the treatment of asthma.