| 摘要 |
<p>5- (SUBSTITUTED PHENYL)HYDANTOINS A series of 5-(substituted phenyl)hydantoins and pharmaceutically acceptable salts thereof are aldose reductase inhibitors useful as agents for treatment of chronic diabetic complications and processes for preparation of said compounds. The hydantoins have the formula: < IMG > I wherein each of X and Y is hydrogen, fluoro, chloro, bromo, (C1-6)alkyl, (C1-6)alkoxy, trifluoromethyl, amino or nitro; Z is S(O)mR or S02NHR1; R is (C1-6)alkyl, chloro, methoxymethyl or < IMG >; m is 0, 1 or 2, with the proviso that when R is chloro, m is 2; R1 is hydrogen, furfuryl, < IMG > ,(C1-6)alkyl, omega-substituted (C2-6)alkyl wherein the substituent is hydroxy or dimethylamino; R4 is hydrogen, fluoro or chloro; n is an integer of from 1 to 4; p is 0 or an integer of from 1 to 4; and each of R2 and R3 is hydrogen, fluoro,chloro, bromo, (C1-6)alkyl, (C1-6)alkoxy, amino or nitro. P.C.(Ph) 6581</p> |
