发明名称 Avermectin 8,9-cyclopropyl compounds, pharmaceutical composition and therapeutic methods of use
摘要 There are disclosed novel avermectin 8,9-cyclopropyl compounds (also referred to as 8,9-dihydro-8,9-methano avermectin compounds). The 8,9-cyclopropyl compounds are prepared by treating an avermectin compound with an iodohalomethane compound in the presence of an activated form of zinc. The avermectin 8,9-cyclopropyl compounds have utility as anti-parasitic agents and compositions for that use are also disclosed. The compounds are also highly potent insecticides against agricultural pests.
申请公布号 US4581345(A) 申请公布日期 1986.04.08
申请号 US19850720763 申请日期 1985.04.08
申请人 MERCK & CO., INC. 发明人 WYVRATT, JR., MATTHEW J.
分类号 A01N43/90;C07H19/01;(IPC1-7):A61K31/71;C07H17/08 主分类号 A01N43/90
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