SELECTIVE ANTITUMOR AGENT

摘要

This invention relates to a selective antitumor agent consisting of a special carrier portion and a voluntary antitumor ingredient. The carrier portion is a monoclonal antibody (MoAb) which is produced by a hybridoma formed by cell fusion of two kinds of animal cells, one of which is an animal cell sensitized by human tumor cell such as spleen cell of BALB/c mouse and another of which is another animal cell such as mouse myeloma cell. The antibody is isolated from the hybridoma and chemically bound with the voluntary antitumor ingredient such as an alkylating agent, an antimetabolic agent, a cytotoxic antibiotic protein or polypeptide, toxin, or alkaloid. The resultant medicine-MoAb conjugate selectively binds with specific tumor cells or tissue having corresponding antigens and the medicine selectively attacks said cells or tissue as its target.