发明名称 |
CEPHALOSPORIN DERIVATIVES |
摘要 |
A cephalosporin derivative of the formula: <IMAGE> I in which R0 is a hydrogen atom or a methyl radical, R1 is any one of the C-3 substituents from antibacterially-active cephalosporins known in the art; R2 is any one of the C-4 substituents from antibacterially-active cephalosporins known in the art; R3 is a hydrogen atom or a 1-6C alkoxy or 1-6C alkylthio radical; X1 is a sulphur or oxygen atom, a CH2 radical or a radical of the formula NR7 in which R7 is a hydrogen atom, a 1-6C alkyl, formyl or benzyl radical; X2 is a nitrogen atom or a radical of the formula N(+)-R7; R4 and R7, and R5 and R6 are a variety of substituents which are described in the specification; and the pharmaceutically-acceptable acid- or base-addition salts thereof. Pharmaceutical compositions, manufacturing processes and intermediates are also described. |
申请公布号 |
DE3173789(D1) |
申请公布日期 |
1986.03.27 |
申请号 |
DE19813173789 |
申请日期 |
1981.12.18 |
申请人 |
ICI PHARMA;IMPERIAL CHEMICAL INDUSTRIES PLC |
发明人 |
JUNG, FREDERIC HENRI;DAVIES, GARETH MORSE |
分类号 |
A61K31/545;A61K31/546;A61P31/04;C07D207/34;C07D209/48;C07D463/00;C07D487/04;C07D501/16;C07D501/18;C07D505/00;(IPC1-7):C07D501/18;C07D498/04;C07D471/04 |
主分类号 |
A61K31/545 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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