FORMATION OF AN IMMUNOSOME EXCLUSIVELY MADE OF VIRAL ANTIGENS RECONSTITUTED ON AN ARTIFICIAL MEMBRANE

摘要

Current virus vaccines made of inactivated particles often induce undesirable local and general secondary reactions. Therefore there is a need for a vaccine that would not contain the substances responsible for these side effects. An immunosome has been constructed, highly immunogenic, which is exclusively made of the antigens attached onto the membrane of a preformed liposome. This immunosome is prepared by providing a quantity of preformed liposomes; providing an antigen viral sub-unit-detergent complex; treating the preformed liposomes to enable antigen sub-units to anchor onto the liposomes so as to form projections on the outer surface of said liposomes; and combining said antigen viral sub-unit-detergent complex with the liposomes obtained above so as to give said immunosomes. This technique recreates a structure that is almost undistinguishable from the virus particle. This immunosome is more immunogenic than the subunits used for its preparation.