ORAL ABSORPTION ENHANCEMENT OF CARBOXYLIC ACID PHARMACEUTICALS USING (5-ALKYL-2-OXO-1, 3-DIOXOLEN-4- YL) METHYL ESTER GROUP

摘要

TITLE OF THE INVENTION ORAL ABSORPTION ENHANCEMENT OF CARBOXYLIC ACID PHARMACEUTICALS USING (5-ALKYL-2-OXO-1,3-DIOXOLEN-4-YL)METHYL ESTER GROUP The (5-R-2-oxo-1,3-dioxolen-4-yl)methyl moiety: < IMG > I wherein R is loweralkyl of 1-6 carbon atoms, especially methyl or t-butyl; when utilized as an ester on a pharmaceutical having a carboxylic acid functionality, enhances oral absorption of the pharmaceutical. This effect is applicable to a broad range of pharmaceutically active substances, including antibiotics, and antihypertensives as well as other classes of therapeutic agents.