发明名称 Clavulanic acid prepn.
摘要 The process comprises clearing of the hot filtered stock in a mixed column of resins, ion exchangers and hydrophobic material with super-saturation of the resins. With adsorption, washing is carried out with NaCl soln. prior to elution of the acid salt. The washing is carried out with water or with 0.5 per cent sodium chloride in water and then with water without appreciable losses. The elution is undertaken with 5 per cent lithium chloride, the more active fractions being selected, with penicillinase inhibition by the hydroxylamine method or by valoration of the acid in the presence of NaOH.
申请公布号 ES8602000(A1) 申请公布日期 1986.03.01
申请号 ES19590005371 申请日期 1984.10.27
申请人 ANTIBIOTICOS, S.A. 发明人
分类号 A61K31/41;C07D491/048;(IPC1-7):C07D491/048 主分类号 A61K31/41
代理机构 代理人
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