发明名称 |
4-DEMETHOXY-4-AMINO-ANTHRACYCLINES |
摘要 |
4-DEMETHOXY-4-AMINO-ANTHRACYCLINES Anthracycline glycosides of the general formula (I): I wherein R1 represents a hydrogen atom or a hydroxyl group, one of R2 and R3 represents a hydrogen atom and the other of R2 and R3 represents a hydrogen atom or a hydroxyl group; and pharmaceutically acceptabls acid addition salts thereof are antitumor agents. These glycosides may be prepared from a daunomycinone derivative of formula (II): in which the 4-amino group is protected. 4-Demethoxy-4-amino-daunomycinone (I) and an earlier intermediate in its preparation, 4-demethoxy-4-amino-7-deoxy-daunomycinone (IX), can be diazotised followed by mild reduction to form 4-demethoxy-daunomycinone or 4-demethoxy-7-deoxy-daunomycinone respectively. 4-Demethoxy-daunomycinone can be converted into another antitumor anthracycline glycoside, 4-demethoxy-daunorubicin. |
申请公布号 |
CA1315775(C) |
申请公布日期 |
1993.04.06 |
申请号 |
CA19880564613 |
申请日期 |
1988.04.20 |
申请人 |
FARMITALIA CARLO ERBA S.R.L. |
发明人 |
CARUSO, MICHELE;SUARATO, ANTONINO;ANGELUCCI, FRANCESCO;ARCAMONE, FEDERICO |
分类号 |
A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61P35/00;C07H15/252 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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