Basic oxime ethers, pharmaceutical compositions possessing antianginal activityand the use of basic oxime ethers for manufactoring medicaments for the treatment of angina.

摘要

The invention relates to pharmaceutical compositions possessing valuable antianginal activity. These compositions show higher activity and more favourable therapeutic indices than the reference compound Prenylamine. Preparation of different kinds of pharmaceutical compositions, such as tablets, dragées, capsules and injectable solutions, containing compounds of general formula (I)

<Chemistry id="chema01" num="0001"><Image id="ia01" he="31" wi="67" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>or their acid addition salts as active ingredients, is disclosed, wherein in formula (I)
<UnorderedLists id="ula01" listStyle="none"><ListItem>R is phenyl or 4-chlorophenyl;</ListItem><ListItem>R<Sup>1</Sup> and R<Sup>2</Sup> each represent hydrogen, methyl or isopropyl: R<Sup>3</Sup> and R<Sup>4</Sup> are hydrogen, or together form a chemical bond;</ListItem><ListItem>n is an integer from 4 to 6;</ListItem><ListItem>A means ethylene or trimethylene if n is 4 or 6: or ethylene, if n is 5.</ListItem></UnorderedLists>