Preparation of 1,1,1,3,3,3-hexafluoropropane-2-ol by hydrogenolysis of hexafluoroacetone hydrate

摘要

1,1,1,3,3,3-hexafluoropropane-2-ol is prepared easily and efficiently by gas-liquid reaction between hydrogen gas and a hexafluoroacetone hydrate such as trihydrate, which is liquid at room temperature, using a suitable catalyst such as active carbon-palladium catalyst. Preferably the gauge pressure of hydrogen gas is 2-10 kg/cm2, and the hydrogenolysis reaction temperature is 70 DEG -100 DEG C. The life of the catalyst can be prolonged by the addition of a small quantity of sodium hydroxide. The addition of a small quantity of aluminum hydroxide is effective in suppressing the formation of fluorine ions in the reaction liquid.