PROCEDIMIENTO PARA PREPARAR 9-(PROPOXIMETIL MONOSUBSTITUIDO EN 1-0 O EN 3-0 O DI-SUBSTITUIDO EN 1,3-0)-PURINAS SUBSTITUIDAS COMO AGENTES ANTIVIRALES

摘要

Compounds useful as antiviral agents are defined by the following formula: (I) wherein R1 is hydrogen, -C(Y)OR7 or -C(O)NHR7 wherein R7 is alkyl of one to twelve carbon atoms, alkenyl of two to twelve carbon atoms, cyclopentyl, cyclohexyl, phenyl or benzyl; R2 is -C(Y)OR7 or -C(O)NHR7 wherein R7 is as defined above; Y is oxygen or sulfur; R3 is hydrogen, halo, thio, lower alkylthio of one to six carbon atoms, azido, NR9R10 wherein R9 and R10 are independently hydrogen or lower alkyl of one to six carbon atoms or -NHC(O)R8 wherein R8 is hydrogen, alkyl of one to nineteen carbon atoms or 1-adamantyl; and (a) R6 is hydrogen, halo, lower alkoxy of one to six carbon atoms, azido, thio, lower alkylthio of one to six carbon atoms, -NR9R10 wherein R9 and R10 are as defined above or -NHC(O)R8 wherein R8 is as defined above and R4 together with R5 is a bond; or (b) R5 together with R6 is a keto group and R4 is hydrogen.