PROCESS FOR MANUFACTURING 3'-ACYLATED MACROLIDE ANTIBIOTICS

摘要

3"-Acylated macrolide antibiotics I [ R3 = alkynoyl (C2-C6) group ; R4 = alkanoyl (C2-C5) group were prepd. The compds. II [ R6 = H, alkanoyl (C2-C4)group; R51 = acetyl chloride were treated with aliphatic carboxylic anhydride (C2-C4) in existence with inorganic bases, and then heated with aliphatic anhydride (C2-C6) in an inert organic solvent. This mixt. was treated with amonia satd. methanol, and heated in methanol to give compds. I.