| 发明名称 |
Retro-inverso analog of the (5-14) decapeptide of equine angiotensinogen, as a specific renin inhibitor with high resistance to enzymatic hydrolysis |
| 摘要 |
There is provided an analog of the (5-14) decapeptide of equine angiotensinogen which is partially inverted at the Phe-Val bond, and which has the formula ProHisProPheHisPheNH +TR <IMAGE> This retro-inverso analog inhibits renin with high resistance to enzymatic degradation and it can be used in the treatment of renin-dependent hypertension.
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| 申请公布号 |
US4560505(A) |
申请公布日期 |
1985.12.24 |
| 申请号 |
US19840612798 |
申请日期 |
1984.05.22 |
| 申请人 |
ENI - ENTE NAZIONALE IDROCARBURI |
发明人 |
PINORI, MASSIMO;VERDINI, ANTONIO S. |
| 分类号 |
C07K14/81;A61K38/00;A61K38/55;A61P43/00;C07K5/02;C07K7/02;C07K7/06;(IPC1-7):C07C103/52 |
主分类号 |
C07K14/81 |
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