ENCAPSULED MOUSE CELL TRANSFORMED WITH BIRD RETROVIRUS-BOVINE GROWTH HORMONE DNA AND ADMINISTRATION OF BGH IN VIVO

摘要

Recombinant DNA constructs having an avian retroviral long terminal repeat (LTR) ligated to the bovine growth hormone gene, were co-transformed into a mammalian cell (mouse) culture in order to obtain a stable cell culture secreting large amounts of bovine growth hormone. The transformed mouse cells were encapsulated in hollow fibers and implanted into animals, thereby producing circulating bovine growth hormone.