NUCLEIC ACID COATED PARTICLES

摘要

PARTICLES ARE PROVIDED WHICH ARE SUITABLE FOR DELIVERY FROM A PARTICLE-MEDIATED DELIVERY DEVICE. THE PARTICLES ARE OBTAINED BY PRECIPITATING A NUCLEIC ACID ON INERT METAL CARRIER PARTICLES IN THE PRESENCE OF A NUCLEIC ACID CONDENSING AGENT AND A METAL ION CHELATING AGENT. ALSO DESCRIBED ARE PROCESSES FOR PREPARING THE PARTICLES, AND THERAPEUTIC METHODS USING THE PARTICLES INCLUDING METHODS OF NUCLEIC ACID IMMUNISATION AND GENE THERAPY.